张转，中国医学科学院医药生物技术所研究员，博士生导师， 2008年本科毕业于陕西师范大学化学系，2014年博士毕业于中国科学院上海有机化学研究所。获得国家海外引进高层次人才青年基金、面上基金等项目资助。 老虎机游戏引进人才，2022年加入老虎机游戏，曾在中国科学院上海有机化学研究所担任研究助理（2014-2017），和美国加州大学洛杉矶分校（2017-2020）以及美国德克萨斯大学休斯顿健康科学中心(2020-2022)从事博士后研究。

研究聚焦于活性先导分子的发现，特别是抗真菌和免疫抑制剂，并解析其生物合成机制。通过合成生物学策略，挖掘与设计高效的酶催化元件，以实现药物绿色智造。同时，课题组还开展抗真菌药物耐药性机制研究，为应对药物耐药挑战提供新思路。目前，团队已在Nat Chem Biol、J Am Chem Soc、Angew Chem Int Ed、PNAS 等国际顶尖学术期刊上以第一或通讯作者发表研究论文9篇，具备扎实的研究基础与持续的创新能力。

老虎机游戏

(1) Qiang Dong#, Niandi Zhang#, Xiaorong Chen#, Jiayi Xuan, Tai Huang, Bo Niu, Zhefei Xu, Qingsong Chen, Jiayi Hu, Zhuan Zhang*, Song Meng*. Concise side-chain macrocyclization in Ahp-bicyclodepsipeptides biosynthesis involves cytochrome P450-catalyzed sequential aromatic hydroxylation and C─N coupling, Angewandte Chemie International Edition, 2025, doi.org/10.1002/anie.202513520. (IF= 16.5)

(2) Chao Yu, Niandi Zhang, Jinmei Li, Mingxin Zheng, Meihui Zhao, Ling-yan Wang, Zhiqiang An*, Gerald F Bills* and Zhuan Zhang*. Concise biosynthesis of antifungal papulacandins, 2025, 147(11): 9037-9042. (IF= 15.6)

(3) Lee Joon Kim#, Masao Ohashi#, Zhuan Zhang#, Dan Tan, Matthew Asay, Duilio Cascio, José A. Rodriguez, Yi Tang* and Hosea M. Nelson*. Prospecting for natural products by genome mining and microcrystal electron diffraction, Nature Chemical Biology, 2021, 17(8): 872-877. (IF= 16.3)

(4) Zhuan Zhang, Yui Tamura, Mancheng Tang, Tianzhang Qiao, Michio Sato, Yoshihiro Otsu, Satoshi Sasamura, Masatoshi Taniguchi, Kenji Watanabe* and Yi Tang*. Biosynthesis of the Immunosuppressant (?)-FR901483, Journal of the American Chemical Society, 2020, 143(1): 132-136. (IF= 15.4)

(5) Zhuan Zhang, Tianzhang Qiao, Kenji Watanabe* and Yi Tang*. Concise Biosynthesis of Phenylfuropyridones in Fungi, Angewandte Chemie International Edition, 2020, 59(45): 19889-19893. (IF= 13.5)

(6) Zhuan Zhang, Cooper S. Jamieson, Yi-Lei Zhao, Dehai Li, Masao Ohashi*, K. N. Houk* and Yi Tang*. Enzyme-Catalyzed Inverse-Electron Demand Diels?Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H, Journal of the American Chemical Society, 2019, 141(14): 5659-5663. (IF= 14.7, C100)

(7) Yu Hu#, Zhuan Zhang#, Yue Yin, Gong-Li Tang*. Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity, Organic Letters, 2019, 22(1): 150-154. (IF= 6.1)

(8) Zhuan Zhang#; Yu-Kang Gong#; Qiang Zhou; Yu Hu; Hong-Min Ma; Yong-Sheng Chen; Yasuhiro Igarashi; Lifeng Pan*; Gong-Li Tang*. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(7): 1554-1559. (IF= 9.5)