刘晓辉,研究员,博士生导师。获得国家级优秀青年人才项目资助。       老虎机游戏引进人才,2023年加入老虎机游戏,曾在美国斯克里普斯研究所、哈佛医学院进行博士后研究工作。
 
	
	 
                            
                        刘晓辉
中国医学科学院药物研究所
助理教授
2023-07-01
药学
药物化学
xiaohuiliu@imm.ac.cn
刘晓辉,研究员,博士生导师。获得国家级优秀青年人才项目资助。       老虎机游戏引进人才,2023年加入老虎机游戏,曾在美国斯克里普斯研究所、哈佛医学院进行博士后研究工作。
长期从事靶向RNA的小分子药物开发,以第一作者或共同第一作者在Nature,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Cell Chem. Biol.等期刊发表论文多篇;获得授权发明专利1项。主持国家自然科学基金面上项目、京津冀基础研究合作专项等多项科技项目。任期刊Pharmaceutical Science Advances青年编委。
 
 
 1. Ting Dong#*, Fabao Zhao#, Mengmeng Wang#, Kaige Lyu#, Jiayu Zhu, Wenru Zhang, Wenzhe Li, Yixuan An, Na Liu, Akhand Pratap Singh, Yue Yang, Dongwei Kang*, Xiaohui Liu*. G3BP1/2 -targeting PROTAC disrupts stress granules dependent ATF4 migracytosis as cancer therapy, J. Am. Chem. Soc. 2025, 147(1), 446-461 2. Yuquan Tong#, Yeongju Lee#, Xiaohui Liu#, Jessica L. Childs-Disney#, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius*, Herbert Waldmann*, Matthew D. Disney*. Nature, 2023, 618:169–179. (F1000) 3. Hafeez S. Haniff#, Xiaohui Liu#, Yuquan Tong, Samantha M. Meyer, Laurent Knerr, Malin Lemurell, Daniel Abegg, Haruo Aikawa, Alexander Adibekian, Matthew D. Disney*. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype. Cell Chem. Biol. 2022, 29(2):300-311.e10. 4. Peiyuan Zhang#, Xiaohui Liu#, Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I. Benhamou, Jared Baisden, Gogce Crynen, Samantha M. Meyer, Michael D. Cameron, Arnab K. Chatterjee, Alexander Adibekian, Jessica L. Childs-Disney, Matthew D. Disney*. Reprogramming of protein-targeted small molecule medicines to RNA via ribonuclease targeting chimeras. J. Am. Chem. Soc. 2021, 143(33):13044-13055. (F1000) 5. Xiaohui Liu#, Hafeez S#. Haniff, Jessica L. Childs-Disney, Anton Shuster, Haruo Aikawa, Alexander Adibekian, Matthew D. Disney*, Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. J. Am. Chem. Soc. 2020, 142(15):6970-6982.老虎机游戏
