杨立成，研究员，博士生导师。2010年毕业于西南大学药学专业，获得学士学位。2010-2011年在中国科学院上海有机化学研究所担任科研助理，从事天然产物全合成研究。2012-2018年在新加坡国立大学有机化学专业攻读博士学位，从事不对称催化研究。曾获得国家优秀自费留学奖学金，国家自然科学基金等资助。
     老虎机游戏引进人才，2022年加入老虎机游戏，曾在美国斯克里普斯研究所进行博士后研究工作，研究内容为化学酶法合成活性天然产物。

研究工作围绕手性药物的不对称催化合成展开，从骨架构建、片段合成到药物分子全合成，开发金属催化环加成反应、借氢反应和酶催化的胺化反应、C-H键羟化反应等合成策略，取得了多项重要的研究成果。截至目前，共发表论文20篇，其中以通讯或第一作者（含共同一作）身份发表15篇高水平论文，包括Nat. Chem.，J. Am. Chem. Soc.，Angew. Chem., Int. Ed.，Adv. Sci.，JACS Au，ACS Catal.等。

老虎机游戏

1. Ni, Z.;^# Zhuang, J.;^# Gao, Y.;^# Gao, G.; Liu, Z.; Su, P.; Cheng, G.-J.;^* Yang, L.-C.^* “Steric-Adaptive Biocatalysis: Imine Reductase-Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines” Adv. Sci. 2025, e10455. (IF=14.3)

2. Liu, Z.-X.;^# Chen, X.;^# Gao, X.; Zhang, S.; Xing, C.; Wang, R.; Hu, K.^* Yang, L.-C.^* “A Novel Type of PSMA-Targeting Ligands via β?Branched Aromatic α?Amino Acid Modification, Bearing Enhanced Tumor Targeting and Reduced Renal Toxicity” J. Med. Chem. 2025, 68, 19661-19672. (IF=6.8)

3. Xu, W.-N.; Gao, Y.-D.; Su, P.; Huang L., He, Z.-L.;^* Yang, L.-C.^* “Progress in Enzyme-Catalyzed C(sp3)-H Amination” ACS Catal. 2024, 14, 14139-14160. (IF=13.1)

4. Li, F.;^# Yang, L.-C.;^# Zhang, J.; Chen, J. S.; Renata, H.^* “Stereoselective Synthesis of β-Branched Aromatic α-Amino Acids via Biocatalytic Dynamic Kinetic Resolution,” Angew. Chem., Int. Ed. 2021, 60, 17680-17685. (IF=16.82)

5. Yang L.-C.;^# Wang, Y.-N.;^# Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan, Y.;^* Shao, Z.;^* Zhao, Y.^* “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions,” Nat. Chem. 2020, 12, 860-868. (IF=21.687, C100)

6. Yang, L.-C.;^# Tan, Z. Y.; Rong, Z.-Q.; Liu, R.; Wang, Y.-N.; Zhao, Y.^* “Pd-Titanium Relay Catalysis Enables Switch of Alkoxide-π-Allyl to Dienolate Reactivity for Spiro-Heterocycle Synthesis," Angew. Chem., Int. Ed. 2018, 57, 7860-7864. (IF=12.257, C100)

7. Wang, Y.-N.;^# Yang L.-C.;^# Rong, Z.-Q.; Liu, T.-L.; Liu, R.; Zhao, Y.^* “Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles,” Angew. Chem., Int. Ed. 2018, 57, 1596-1600. (IF=12.257, C100)

8. Rong, Z.-Q.;^# Yang, L.-C.;^# Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.;^* Zhao, Y.^* “Nine-membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” J. Am. Chem. Soc. 2017, 139, 15304-15307. (IF=14.357, C100)

9. Yang, L.-C.;^# Rong, Z.-Q.;^# Wang, Y.-N.; Tan, Z. Y.; Wang, M.; Zhao, Y.^* “Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition,” Angew. Chem., Int. Ed. 2017, 56, 2927-2931. (IF=12.102, ESI, C100)

10. Yang, L.-C.;^# Wang, Y.-N.; Zhang, Y.;^* Zhao, Y.^* ACS Catal., 2017, 7, 93-97. “Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen,” (IF=11.403)