杨柳柳，研究员，博士研究生导师。主持中国医学科学院创新工程项目一项，国家自然科学基金优秀青年科学基金（海外）一项，国家自然科学基金面上项目一项，天津市自然科学基金青年项目A类一项，作为课题负责人参与国家重点研发项目一项。 老虎机游戏引进人才，2024年加入老虎机游戏。曾在美国康奈尔大学威尔医学院从事博士后研究（2019年9月至2024年5月）。

长期从事人多能干细胞来源的类器官的开发及应用等方面的研究。建立了人多能干细胞分化的三胚层多种组织细胞及类器官平台，研究了病毒感染以及免疫细胞与组织细胞的互作，筛选出具有抗病毒和细胞保护作用的药物。同时，解析了干细胞自我更新调控及免疫细胞谱系建立的分子机制。以第一作者（含共同）或通讯作者在 Nature、Cell Stem Cell、Nature Methods、Nature Immunology 等期刊发表论文17篇，其中高被引论文4篇，总引用次数超过3000次。

老虎机游戏

1. Han Y*, Leng D, Zhang T, Ge J, Fang Y, Lu T, Dong X, Nair MS, de Silva N, Han Z, Jiao T, Huang Y, Zhao M, Saqi A, Hibshoosh H, Meng Z, Xiang JZ, Pan C, Sun Y, Ho DD, Evans T, Liu J, Yang L*, Que J*, Chen S*. A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection. Adv Sci (Weinh). 2025 Sep;12(36):e03932. doi: 10.1002/advs.202503932. Epub 2025 Jul 25. PMID: 40712141; PMCID: PMC12463091.

2. Yang L^#*, Han Y^#, Zhang T^#, Dong X, Ge J, Roy A, Zhu J, Lu T, Jeya Vandana J, de Silva N, Robertson CC, Xiang JZ, Pan C, Sun Y, Que J, Evans T, Liu C, Wang W, Naji A, Parker SCJ, Schwartz RE*, Chen S*. Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. 2024 Nov 7;31(11):1612-1629.e8.

3. Yang L^#, Kim T. W^#, Han Y^#, Nair M. S^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo S.Y, Lacko L A, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, Valk P. v. d, Titulaer M. J, Spoor J. KH, Brien R.L. FO, Bugiani M, Berg W. DJ V d, Schwartz R. E*, Ho D. D*, Studer L*, Chen S*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024 Feb 1;31(2):196-211.e6.

4. Han Y^#, Tan L^#, Zhou T^#, Yang L^#, Carrau L^#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team; Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022 Oct 6;29(10):1475-1490.e6. doi: 10.1016/j.stem.2022.09.008. PMID: 36206731; PMCID: PMC9550219.

5. Han Y^#, Yang L^#, Lacko LA, Chen S*. Human organoid models to study SARS-CoV-2 infection. Nat Methods. 2022 Apr;19(4):418-428. doi: 10.1038/s41592-022-01453-y. Epub 2022 Apr 8. PMID: 35396481.

6. Yang L^#, Nilsson-Payant BE^#, Han Y^#, Jaffré F^#, Zhu J^#, Wang P, Zhang T, Redmond D, Houghton S, M?ller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD*, Schwartz RE*, tenOever BR*, Evans T*, Chen S*. Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem Cell Reports. 2021 Sep 14;16(9):2274-2288. doi: 10.1016/j.stemcr.2021.07.012. Epub 2021 Jul 20. Erratum in: Stem Cell Reports. 2021 Oct 12;16(10):2565. doi: 10.1016/j.stemcr.2021.09.008. PMID: 34403650; PMCID: PMC8289700.

7. Yang L^#, Han Y^#, Jaffré F^#, Nilsson-Payant BE^#, Bram Y, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Xiang J, Ho DD*, tenOever BR*, Schwartz RE*, Evans T*, Chen S*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 Jun 25;129(1):33-46.

8. Han, Y^#, Duan, X^#, Yang, L^#, Nilsson-Payant, B.E^#, Wang, P^#, Duan, F^#, Tang, X^#, Yaron, T.M^#, Zhang, T, Uhl, S, Bram Y, Richardson, C, Zhu, J, Zhao, Z, Redmond. D, Houghton, S, Nguyen, D.T, Xu, D, Wang, X, Jessurun, J, Borczuk, A, Huang, Y, Johnson, J.L, Liu, Y, Xiang, J, Wang, H*, Cantley, L.C*, tenOever, B.R*, Ho, D.D*, Pan, F*, Evans, T*, Chen, H.J*, Schwartz, R.E*, Chen, S*. Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids. Nature. 2021 Jan;589(7841):270-275. (C100)

9. Yang L^# , Han Y^#, Nilsson-Payant BE^#, Gupta V^#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC*, Ho DD*, tenOever BR*, Evans T*, Schwartz RE*, Chen S*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. (C100)

10. Liu B^#, Ye B^#, Yang L^#, Zhu X^#, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017 May;18(5):499-508. doi: 10.1038/ni.3712. Epub 2017 Mar 20. PMID: 28319097. (C100)