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血液病医院

  • 姓 名:

    饶书权

  • 单 位:

    中国医学科学院血液学研究所(血液病医院)

  • 教职岗位:

    助理教授

  • 聘任时间:

    2021-07-29

  • 一级学科:

    临床医学

  • 二级学科:

    干细胞与再生医学

  • 联系方式:

    raoshuquan@ihcams.ac.cn

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2021140007

个人简介

饶书权,1987年8月出生,研究员,博士生导师。中国医学科学院血液病医院(中国医学科学院血液学研究所)任课题组长。获国家自然科学基金优秀青年基金(海外)、国家自然科学基金面上项目、国家重点研发计划等项目资助。 老虎机游戏引进人才,2021年加入老虎机游戏,曾在美国圣裘德儿童研究医院和哈佛医学院/波士顿儿童医院开展博士后科研工作。


主要研究内容

长期从事血液系统疾病细胞和基因治疗研究。课题组长期致力于血液系统疾病细胞和基因治疗,开发了一系列可用于人类原代细胞基因编辑和功能筛选的新方法,在造血干细胞基因治疗和NK细胞治疗方向取得了多项原创性科研成果。近五年来,在Cell Stem Cell(2021)、Cell Genomics(2024)、Nat Commun(2022,2025)、J Clin Invest(2022)、Cell Rep(2024)、Am J Hum Genet(2021)、Genome Med(2021)、Nucleic Acids Res(2024)等期刊发表SCI论文20余篇,被Nature、Cell和NEJM等期刊引用2500余次。培养博士、硕士、博士后10余名。


代表性成果

老虎机游戏

1. Xinyue Wang#, Ning Li#*, Lu Han#, Ou Qiao#, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao*, Zichuan Liu*, Yanhua Gong*. Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb. Nature Communications, 2025, 16(1):1044.

2. Mutong Li#, Zhaohui Cai#, Shucheng Song#, Xinmin Yue, Wenyu Lu, Shuquan Rao*, Chuanbo Zhang*, Chaoyou Xue*. EcCas6e-based antisense crRNA for gene repression and RNA editing. Nucleic Acids Res, 2024, 52(14):8628-8642.

3. Yao Yao#*, Zhiwei Zhou#, Xiaoling Wang#, Zhirui Liu#, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue*, Shuquan Rao*. SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution. Cell Genomics, 2024, 4(7):100583.

4. Chen Yang#, Zhiwei Zhou#, Xuanlong Sun, Haiyan Ju, Xinmin Yue, Shuquan Rao*, Chaoyou Xue*. PAMless SpRY exhibits a preference for the seed region for efficient targeting. Cell Rep, 2024, 43(5):114225.

5. Marsha Wheeler#, Adrienne Stilp#, Shuquan Rao#, Bjarni Halldorsson, Doruk Beyter, …, Daniel Bauer#, Paul L. Auer*, Alexander Reiner*. Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program. Nat Commun, 2022, 13(1):7592.

6. Fuquan Zhang#*, Shuquan Rao#, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, Ning Zhang, Lin Tian, Jianmin Yuan, Guoqiang Wang, Lei Cai, Mingqing Xu, Ancha Baranova*. Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder. J Clin Invest, 2022, 132(3):e145942.

7. Shuquan Rao# , Yao Yao# , Josias Soares de Brito# , Qiuming Yao, Anne H Shen, …, Benhur Lee, Peter E Newburger, Daniel E Bauer* . Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell, 2021, 28(5):833–845.e5.

8. Yao Hu#, Adrienne M Stilp#, Caitlin P McHugh#, Shuquan Rao#, Deepti Jain, …, Daniel E Bauer, Matthew P Conomos, Alexander P Reiner*. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet, 2021, 108(5):874-893.

9. Yao Yao#, Fei Ye#, Kailong Li#, Peng Xu, Wenjie Tan, Quansheng Feng, Shuquan Rao*. Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduct Target Ther, 2021, 6(1):85. (IF = 38.1)

10. Yao Yao, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan Ren, Lu Chen*, Shuquan Rao*. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol, 2020, 3(1):790.