姚瑶，研究员，博士研究生导师。主持国自然面上项目和医科院创新工程项目各1项，参与国家重点研发计划1项。 老虎机游戏引进人才，2021年加入老虎机游戏。曾在成都中医药大学基础医学院任讲师/助理研究员（2015年9月至2018年8月）。

长期从事人类造血干细胞基因编辑与血液系统遗传病的基因治疗研究，近五年主要学术成果包括：1）率先建立人造血干细胞CRISPR文库筛选，解析重症先天性粒细胞减少症机制，开发造血干细胞通用型基因治疗策略；2）设计非编码区单碱基分辨率CRISPR筛选策略，精准鉴定调控元件及致病变异；3）开发新型基因编辑工具，结合多组学数据分析致病变异及机制。研究成果获国际同行广泛关注和高度评价，为血液疾病治疗提供了新手段、新机制、新靶点。

老虎机游戏

1. Yao Yao^#*, Zhiwei Zhou^#, Xiaoling Wang^#, Zhirui Liu^#, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue*, Shuquan Rao*. SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution. Cell Genom 2024, Jun 17;4(7):100583.

2.Yao Yao^#, Jiaxuan Cao^#, Wentian Wang, Boya Liu, Xiaolei Pei, Lei Zhang, Shuquan Rao*. Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins. CRISPR J 2022;5(6):843-853.

3. Shuquan Rao^#, Yao Yao^#, Josias Soares de Brito^#, Qiuming Yao, Anne H Shen, Ruth E Watkinson, Alyssa L Kennedy, Steven Coyne, Chunyan Ren, Jing Zeng, Anna Victoria Serbin, Sabine Studer, Kaitlyn Ballotti, Chad E Harris, Kevin Luk, Christian S Stevens, Myriam Armant, Luca Pinello, Scot A Wolfe, Roberto Chiarle, Akiko Shimamura, Benhur Lee, Peter E Newburger*, Daniel E Bauer*. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell 2021;28(5):833-845. (Featured article)

4. Yao Yao^#, Fei Ye^#, Kailong Li^#, Peng Xu, Wenjie Tan, Quansheng Feng, Shuquan Rao*. Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduction Targeted Ther 2021, 6(1):85.

5. Yao Yao, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan Ren, Lu Chen*, Shuquan Rao*. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol 2020,3(1):790.

6. Yao Yao^#, Hongfei Song^#, Fanshuang Zhang^#, Jibin Liu, Dong Wang, Quansheng Feng, Shuquan Rao*, Cen Jiang*. Genetic predisposition to blood cell indices in relation to severe COVID-19. J Med Virol 2023.95(1):e28104. (IF: 12.7)

7. Shuquan Rao^#*, Yao Yao^#, Daniel E Bauer*. Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation. Genome Med 2021;13(1):41.

8. Xinwen Chen^#, Jingjing Du^#, Shaowei Yun, Chaoyou Xue*, Yao Yao*, Shuquan Rao*. Recent advances in CRISPR-Cas9-based genome insertion technologies. Mol Ther Nucleic Acids 2024;35(1):102138.