李贵登，中国医学科学院/老虎机游戏、苏州系统医学研究所教授/研究员。国家自然基金青年科学基金项目（A类），海外高层次青年人才项目和江苏省“杰出青年基金项目”获得者。入选江苏省双创人才和江苏省“333工程”中青年科技领军人才。曾于加州理工学院诺贝尔奖获得者David Baltimore实验室完成博士后训练，多年来聚焦于肿瘤T细胞免疫的分子机理研究，开发新型肿瘤免疫治疗技术和方法。
      老虎机游戏引进人才，2019年加入老虎机游戏。

专注探究肿瘤T细胞免疫的分子机理研究，开发新型肿瘤免疫治疗技术和方法。以通讯作者（含共同）在Cancer Cell (2篇)、Immunity、Nature Metabolism、Nature Methods、Nature Communications 、Blood、Advanced Science和Cell Reports等国际权威期刊发表论文10 余篇，为Nature Reviews Immunology、Nature Methods (2篇)和Cell Metabolism (2篇)等期刊撰写综述和评论。承担国家自然科学基金项目、国家科技创新2030重大项目以及医科院创新工程和基础等科研项目10余项。担任中国免疫学会理事会理事和中国免疫学会肿瘤免疫与生物治疗分会委员等职务。

老虎机游戏

1. Kaili Ma#, Hongcheng Cheng#, Lin Wang#, Han Xiao#, Fenghua Liu#, Yu Yang, Zhen Xiao, Kun Tang, Shicheng Li, Gang Wang, Minmin Ge, Jiajia Wang, Xiaowei Liu, Hai-Xi Sun, Ziyi Luo, Zhimin Gu*, Ping-Chih Ho*, Guideng Li*, Lianjun Zhang*. Succinate preserves CD8+ T cell fitness to augment antitumor immunity. Immunity. 2025; 58(10): 2505-2523.e8. (IF=33.2)

2. Shanshan Zhang#, Yan Zhou#, Zhonghua Liu#, Yuqian Wang#, Xiang Zhou, Haiwen Chen, Xinyu Zhang, Yanhong Chen, Qisheng Feng, Xiaoping Ye, Shanghang Xie, Musheng Zeng, Weiwei Zhai, Yixin Zeng*, Sumei Cao*, Guideng Li*, Miao Xu*. Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma. Cancer Cell. 2025; 43(8): p1423-1441.e10. (IF=47.2, ESI)

3. Yajing Qiu#, Yapeng Su#, Ermei Xie#, Hongcheng Cheng#, Jing Du#, Yue Xu, Xiaoli Pan, Zhe Wang, Daniel G. Chen, Hong Zhu, Philip D. Greenberg*, Guideng Li*. Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity. Cancer Cell. 2025; 43(1): 103–121.e8. (IF=47.2)

4. Yuqian Wang#, Zhe Wang#, Juan Yang#, Xiaobo Lei, Yisu Liu, Luke Frankiw, Jianwei Wang*, Guideng Li*. Deciphering membrane-protein interactions and high-throughput antigen identification with cell doublets. Advanced Science. 2024; 11(13): e2305750. (IF=15.6)

5. Zhe Wang#, Jingzhe Shang#, Yajing Qiu#, Hongcheng Cheng, Mengyuan Tao, Ermei Xie, Xin Pei, Wenhui Li, Lianjun Zhang*, Aiping Wu*, Guideng Li*. Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity. Cell Reports. 2024; 43(2): 113796. (IF=8.1)

6. Yisu Liu#, Yuqian Wang#, Zhiqiang Peng, Guideng Li*, Jianwei Wang*. T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19. hLife. 2023; 1(1): 57–61. (暂无影响因子数据)

7. Hongcheng Cheng#, Yajing Qiu#, Yue Xu#, Li Chen#, Kaili Ma, Mengyuan Tao, Luke Frankiw, Hongli Yin, Ermei Xie, Xiaoli Pan, Jing Du, Zhe Wang, Wenjie Zhu, Lu Chen*, Lianjun Zhang*, Guideng Li*. Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness. Nature Metabolism. 2023; 5(2): 314–330. (IF=21.2, ESI) 

8. Yapeng Su#, Melissa E. Ko#, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P. Nolan, Wei Wei, Sylvia K. Plevritis, Guideng Li*, David Baltimore*, James R. Heath*. Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line. Nature Communications. 2020; 11(1): 2345. (IF=12.121, C100)

9. Guideng Li*#, Michael T. Bethune*#, Stephanie Wong, Alokv Joglekar, Michael T. Leonard, Jessica K. Wang, Jocelyn T. Kim, Donghui Cheng, Songming Peng, Jesse M. Zaretsky, Yichen Su, Yicheng Luo, James R. Heath, Antoni Ribas, Owen N. Witte, David Baltimore*. T cell antigen discovery via trogocytosis. Nature Methods. 2019; 16(2): 183–190. (IF=28.467, C100)

10. Guideng Li*#, Alex Yick-Lun So, Reeshelle Sookram, Stephanie Wong, Jessica K. Wang, Yong Ouyang, Peng He, Yapeng Su, Rafael Casellas, David Baltimore*. Epigenetic silencing of miR-125b is required for normal B-cell development. Blood. 2018; 131(17): 1920–1930. (IF=16.562)